Seven Deadly Sins – the Biology of Human Frailty

Philip Ball in The Guardian:‘From Adam has sprung one mass of sinners and godless men,” wrote St Augustine, arguably the key architect of the Christian doctrine of original sin. The notion that babies are born with this indelible stain, the residue of Adam’s fall in Eden, can seem one of the most pernicious features of Christian dogma. But as Guy Leschziner argues in Seven Deadly Sins, we could interpret Augustine’s austere judgment as an acknowledgment that we are inherently inclined to do things we shouldn’t. The catalogue of seven direst vices first adduced by Tertullian and immortalised in Dante’s Divine Comedy – pride, greed, wrath, envy, lust, gluttony and sloth – may seem arbitrary, but we can all recognise aspects of them in ourselves.

Leschziner, a consultant neurologist at Guy’s Hospital in London, explores the physiological and psychological roots of these “failings” and argues that, in mild degree, all might be considered not just universal but necessary human attributes. The goal, he implies, is not to renounce them but to align our natural impulses with the demands of living healthily and productively in society. Seven Deadly Sins takes the case-study format pioneered by Oliver Sacks in using dysfunction to explore the neurological origins of behaviour. It is a profoundly humane book, occasionally compromised by excessive clinical detail and perhaps more so by its lack of wider context.

Like Sacks, Leschziner writes with great empathy and compassion about patients facing often heartbreaking situations. Rhett has witnessed his wife, Becky (“the sweetest girl I’d ever met”), turned acutely irritable as well as near-catatonically apathetic by Huntington’s disease (sloth). An undiagnosed neurological condition lies at the root of Sarah’s conviction that her husband is cheating on her (envy). Easy-going Jono experiences outbursts of violent aggression related to his epilepsy (wrath).

Seven Deadly Sins effectively and usefully counters the idea that deviations from norms of, say, anger, appetite, or motivation stem from differences between brains that are “healthy” or “ill”. Equally, Leschziner challenges the common view that only problems originating in bodily disfunction are “real” while ones that seem essentially psychological are imagined or made up. “These views taint clinical medicine and wider society”, he writes. Surprisingly, he does not relate that to long covid, which has highlighted the prejudice at the same time as problematising the distinction.

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